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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAMTS12
All Species:
0.91
Human Site:
S1108
Identified Species:
2.22
UniProt:
P58397
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P58397
NP_112217.2
1594
177676
S1108
P
S
E
E
N
V
S
S
S
D
T
G
P
T
S
Chimpanzee
Pan troglodytes
XP_517836
1524
170558
Y1074
T
W
P
V
T
P
F
Y
N
T
L
T
K
G
P
Rhesus Macaque
Macaca mulatta
XP_001090049
676
76654
R229
L
W
R
E
K
W
E
R
H
N
L
P
S
R
S
Dog
Lupus familis
XP_536508
1351
150913
G904
S
A
S
C
G
P
H
G
E
K
K
R
T
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q811B3
1600
177774
E1112
L
S
I
Q
P
D
D
E
N
V
S
S
S
A
I
Rat
Rattus norvegicus
Q1EHB3
1595
175796
P1086
H
I
R
P
T
E
P
P
S
D
S
P
V
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_424749
1118
125075
I671
T
E
R
A
P
A
V
I
D
G
T
Q
C
N
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001343371
949
105988
P502
Q
P
V
R
C
F
E
P
E
V
G
V
V
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396340
1195
134772
G748
Y
D
K
N
D
G
P
G
Y
K
E
V
I
I
V
Nematode Worm
Caenorhab. elegans
Q19791
2150
242563
S1168
T
K
P
C
H
R
E
S
C
P
K
Y
K
L
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.2
41.7
74.5
N.A.
80.4
44.9
N.A.
N.A.
30.1
N.A.
35.3
N.A.
N.A.
29
25.4
N.A.
Protein Similarity:
100
94.5
42.2
78.6
N.A.
87.5
60.9
N.A.
N.A.
42.3
N.A.
46
N.A.
N.A.
43.7
39.9
N.A.
P-Site Identity:
100
0
13.3
0
N.A.
6.6
13.3
N.A.
N.A.
6.6
N.A.
0
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
100
6.6
20
6.6
N.A.
26.6
26.6
N.A.
N.A.
13.3
N.A.
0
N.A.
N.A.
13.3
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
10
0
10
0
0
0
0
0
0
0
10
10
% A
% Cys:
0
0
0
20
10
0
0
0
10
0
0
0
10
0
0
% C
% Asp:
0
10
0
0
10
10
10
0
10
20
0
0
0
0
0
% D
% Glu:
0
10
10
20
0
10
30
10
20
0
10
0
0
10
10
% E
% Phe:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
10
0
20
0
10
10
10
0
10
10
% G
% His:
10
0
0
0
10
0
10
0
10
0
0
0
0
0
0
% H
% Ile:
0
10
10
0
0
0
0
10
0
0
0
0
10
10
10
% I
% Lys:
0
10
10
0
10
0
0
0
0
20
20
0
20
0
0
% K
% Leu:
20
0
0
0
0
0
0
0
0
0
20
0
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
10
0
0
0
20
10
0
0
0
10
0
% N
% Pro:
10
10
20
10
20
20
20
20
0
10
0
20
10
10
10
% P
% Gln:
10
0
0
10
0
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
0
0
30
10
0
10
0
10
0
0
0
10
0
10
0
% R
% Ser:
10
20
10
0
0
0
10
20
20
0
20
10
20
0
20
% S
% Thr:
30
0
0
0
20
0
0
0
0
10
20
10
10
10
10
% T
% Val:
0
0
10
10
0
10
10
0
0
20
0
20
20
10
10
% V
% Trp:
0
20
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
10
10
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _